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| No, I still do not recommend the chronic (ab-)use of NSAIDs, bro. |
As you may remember, previous studies have yielded conflicting evidence with respect to the ability of NSAID to accelerate muscle healing and thus accelerater and ultimately shorten the adaptational process.
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To assess, whether the ingestion of ibuprofen would, as the scentists suspected alter satellite cell response and time course of regeneration in the experimentally injured skeletal muscle of young healthy men, biopsies were collected from the vastus lateralis muscles before and after stimulation (2.5 h and 2, 7, and 30 d) and were assessed for satellite cells and regeneration by immunohistochemistry and real-time RT-PCR. In conjunction with the likewise measured length of the telomeres, the scientists expected to be able to determine the actual effect of NSAIDs on the post-exercise recovery process.
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| Figure 1: CD68 and CCL2 are only two markers of the damage/repair process that show a clear phase-shift (meaning earlier elevation = earlier repair) with IBU. Furthermore the ibuprofen "preload" prevented the formation of collage (right) in the muscle after 30 days (Mackey. 2016). |
The bad news is that the chronic consumption of NSAIDs is nothing a healthy individual should consider - even if it prevents your muscle from collagen depositions (see Figure 1, right); and still, if we could get the benefits observed in the study at hand without the potential long-term side effects of common NSAIDs, they could be a game changer... at least for elderly individuals, in whom the recruitment of satellite cells and thus process of muscle repair appears to be impaired by aging.
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| The statement that NSAIDs could be particularly beneficial for elderly is more than an unsupported hypothesis. In February, I already wrote about the type-I-specific muscle-building effects of COX-inhibitors | learn more. |
As Mackey et al. point out, NSAIDs (in this case IBU) is eventually shifting the entire time course of satellite cell, myofiber - and that without effects on muscle telomere length in human skeletal muscle in vivo. In view of the highly damaging electrostimlation method, it does yet remain to be seen how beneficial effect of NSAID ingestion are when the damate to the muscle is less pronounced and thus in a more physiological range | Leave a comment and tell me what you think on Facebook!
- Mackey, Abigail L., et al. "Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication." The FASEB Journal (2016): fj-201500198R.