Regular Meals Promote Thermogenic Effect of Food - 22% to 50% Higher Postprandial Thermogenesis in Healthy Women

While the ads for many fat burners tell you just that, thermogenesis is not the #1 determinant of whether you're lean or fat. It is just one of a bazillion factors that influence your energy balance which in turn controls your weight.

Thermogenesis is (falsely) treated like the holy grail in fat loss supplement ads. When all is said and done, though, even a 100% increase in thermogenesis, which has nothing to do with a 100% increase in total energy expenditure, is usually easily compensated for by increased energy intakes in the average and extraordinary male or female dieter.

Against that background you may be asking yourselves why the latest study from the School of Life Sciences at the University of Nottingham even made the "SuppVersity newsworthy"-cut. Well, the answer can be seen in Figure 1, which tells you that modulating the eating patterns in said randomized crossover trial didn't just affect the extent of postprandial thermogenesis, but also the weight, body fat and, in particular, the 'waist trajectory' of the subjects, 9 obese women (mean ± SD BMI: 33·3 ± 3·1 kg/m²).
To ascertain whether modulating the regularity of meal pattern over two weeks would affects the thermogenic response to a test meal and anthropometric measurements in obese women, Alhussain et al. had their subjects follow irregular and regular meal patters for 2 weeks, each:

• regular meal pattern - 6 meals/day
• irregular meal pattern -  varying from 3 to 9 meals/day

In that, it is important to note that "[i]n the two intervention periods, identical foods were provided in amounts designed to keep body weight stable" (Alhussain. 2016). For the testing sessions, the participants attended the laboratory after an overnight fast pre and post each intervention period.

"On arrival, measurements were made of body weight, body composition, waist circumference and waist to hip ratio. Resting energy expenditure was then assessed by using indirect calorimetry, fasted and during the 3 h period after consumption of a milkshake, test drink (50 % CHO, 15 % protein and 35 % fat of energy content)" (Alhussain. 2016).

As already hinted at, the scientists observed significant changes in the postprandial thermogenic response and non-significant effects on the subjects body composition.

Figure 1: Changes in markers of body composition during the two 2-week periods (Alhussain. 2016).

More specifically, the regular meal pattern that allowed for weight and body fat stability and even triggered a non-significant decrease in waist circumference. The irregular pattern, on the other hand, produced an albeit statistically non-significant increase in body weight and body fat - a change, of which we can hypothesize that it would reach statistical significance in the weeks to come.
In view of the lack of strict dietary control outside of a metabolic ward, it is hard to say whether the effects on body composition (Figure 1) were triggered solely by the decrease in thermogenesis (Figure 2) due to the irregular meal pattern. As I've pointed out in countless previous SuppVersity articles these effects may just as well be caused by increases in food intake, which are never (or at least rarely ;-) 100% accurately reported by subjects of clinical trials.

Figure 2: Postprandial extra energy expenditure due to thermogenesis (kcal/3h) before and after 2-weeks on regular or irregular meal pattern in 9 obese women [mean ± SD BMI: 33·3 ± 3·1 kg/m² | Alhussain. 2016).

Eventually, the lack of dietary control must not necessarily be a disadvantage. After all, there's no strict dietary control in the real world, either. Therefore, any study that tightly controls their subjects food intake will fail to portray a correct picture of its subjects real lives - lives in which the average subject shows a very low adherence to his/her (self-)prescribed diet and will thus (just as it may have been the case in this study) simply eat, when he/she is hungry, even if his/her meal plan tells him/her not to do so - and regular meal patterns certainly help avoiding hunger pangs.
References:

• Alhussain, et al. "Deleterious effects of irregular meal pattern on dietary thermogenesis in obese women." Proceedings of the Nutrition Society 75 (2016): OCE1, E6.
• Farshchi, H. R., M. A. Taylor, and I. A. Macdonald. "Decreased thermic effect of food after an irregular compared with a regular meal pattern in healthy lean women." International journal of obesity 28.5 (2004): 653-660.